I got out of the “surplus hardware” a while ago; way too expensive and noisy to run, so super recommend ditching the poweredge. for home use, I ended up just going with a USB3 JBOD for storage, and a Intel NUC (which I think they don’t make anymore). it runs a ton of virtualized servers under kvm, a virtualized NAS, all without issue because it honestly spends most of its time nearly idle. point is: it’s definitely nice to have it all in one case and with high speed storage but maybe having to find something that can house a ton of drives isn’t a strict need if you aren’t actually going to put a ton of load on it.
I’ve used rclone with backblaze B2 very successfully. rclone is easy to configure and can encrypt everything locally before uploading, and B2 is dirt cheap and has retention policies so I can easily manage (per storage pool) how long deleted/changed files should be retained. works well.
also once you get something set up. make sure to test run a restore! a backup solution is only good if you make sure it works :)