Long Covid Symptoms

Check the long list of just the mental Long Covid (aka Post-Acute Squelae of COVID or PASC) symptoms:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959835/

The ER Connection

Recent findings involve research with the endoplasmic reticulum that appears to go off the rails when over-stressed breaking the mitochondria within a cell robbing it of ATP production and increasing lactate (related to metabolic acidosis) in the body:

• https://www.healthrising.org/blog/2023/08/16/nih-mitochondria-chronic-fatigue-syndrome/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140510/

My current reasoning is somehow to recover you’ve got to pace yourself just enough to encourage new mitochondria to form, but not so much that you experience PEM/crashing. The ME/CFS people have been discussing pacing for years. So:

Fail With

• staying in bed for weeks doing as little as possible (a very slow success?-- mitochondria aren’t encouraged to form)
• trying to train it away with exercise/exertion (a quick fail-- the stressed ER will break mitochondria and flood body with lactate and set you back with a slew of acidosis-caused symptoms that will take time for the body to resolve. e.g. kidneys excreting the acid, COVID diabetes from gluconeogensis of lactate into glucose in order to raise the body’s pH away from acidosis)

Possibly Succeed With

• small exertions (signal need for more mitochondiria) before PEM followed by “intense” resting, cold exposure (ice baths or cold showers) and kidney-friendly diets (see: https://www.niddk.nih.gov/health-information/kidney-disease/chronic-kidney-disease-ckd/eating-nutrition ) to help the body process the acidity of lactate out to reduce ER stress.

This was a purposefully supplement-free/drug-free plan.

So, is there an opposite “disease” where the deceleration-sensitive neurons are non-functional? What would that look like?